Endocrine Abstracts

Background: In patients with testicular dysgenesis syndrome, reduced semen quality and testicular cancer are common. We report a case of a testicular tumour in a patient with a history of cryptorchidism and oligoasthenospermia. He had an unusual hormonal profile, which was not fully explained by the pathological findings.Case: A 31-year-old man was referred to our tertiary care andrology unit for primary infertility with a history of bilateral orchidopex...

Testicular adrenal rest tumours (TARTs) are benign tumours deemed to originate from ectopic adrenal cells that descend with the testes during fetal development. These cells grow under chronic ACTH stimulation, typically in patients with congenital adrenal hyperplasia (CAH). TARTs have also been rarely described in other conditions characterised by chronically elevated ACTH, such as autoimmune primary adrenal insufficiency (PAI). These are benign lesions, but could be misdiagno...

Introduction: Epigenetic and genetic alterations contribute to cancer initiation and progression. These alterations may be playing a determinant role in the development of pituitary adenomas (PAs). One of these epigenetic processes is the DNA methylation and, specifically, methylation of Tumour Suppressor Genes (TSG). TSG are key elements that allow the maintenance of cellular homeostasis. Due to epigenetic changes are reversible, a better understanding of the underlying epige...

Background and aims: Primary hyperparathyroidism (PHPT) often presents without classical symptoms such as overt skeletal disease or nephrolithiasis. Treatment strategies have been widely discussed. The objective of our research was to study the effect of parathyroidectomy (PTX) compared to observation (OBS) on skeletal outcomes such as bone mineral density (BMD).Subjects and methods: A retrospective observational study was conducted between 1991 and 2014...

Background and aims: Primary hyperparathyroidism (PHPT) is a common endocrine disorder with different epidemiological patterns among countries. The incidence of PHPT is unknown in Spain. The aim of our study is to assess the prevalence and incidence of diagnosed PHPT in adults between 1970 and 2014 in Santander, a population of 290.000 inhabitants, located in the north of Spain.Subjects and methods: All patients diagnosed with primary hyperparathyroidism...

Multiple benign symmetric lipomatosis (Madelung’s disease, Launois–Bensaude syndrome) is significantly rare disease characterised by symmetrical focal deposition of adipose tissue in the neck, upper part of the arms, back, pelvis, and thigh. Although its etiology is uncertain, it has been associated with genetic factors, mitochondrial inheritance and alcoholism. Its pathogenesis seems to include a dysfunction of cAMP and levels of catecholamines in adipocytes. This c...

Introduction: Adipose tissue disturbances (lipodystrophy and obesity) are prevalent in patients infected with HIV. Our aims were to evaluate the prevalence of obesity and the association with lipodystrophy, the effect of gender, age, viral replication, duration of disease and cART in a population of HIV patients under cART.Methods: In this retrospective study, 580 patients were included. The characteristics of the population are presented through percent...

Introduction: Subacute thyroiditis is usually a self-limited pathology, possibly of viral aetiology, defined by cervical pain and sometimes systemic symptoms. Its association with autoimmune diseases doesn’t seem to be more frequent than in the general population.Clinical case: Clinical findings of thyrotoxicosis with 3 weeks of evolution associated with anterior cervical pain and fever up to 38 °C. The patient presented with recurrent mouth so...

Background: In patients with testicular dysgenesis syndrome, reduced semen quality and testicular cancer are common. We report a case of a testicular tumour in a patient with a history of cryptorchidism and oligoasthenospermia. He had an unusual hormonal profile, which was not fully explained by the pathological findings.Case: A 31-year-old man was referred to our tertiary care andrology unit for primary infertility with a history of bilateral orchidopex...

Introduction: Ultrasound (US) thyroid examination is the most common method to assess thyroid nodules risk of malignancy and select nodules for fine-needle aspiration biopsy (FNAB). Thyroid US evaluation performed by endocrinologists has recently increased in Spain.Objectives: To evaluate the predictive value of US features of malignancy in differentiating benign and malignant thyroid lesions in a Thyroid Nodule Clinic.Patients and...